Research AG Hornung

In our research projects, we are trying to understand what mechanisms are employed by our innate immune system to distinguish self from non-self...

Research AG Endl

The work of the group focuses on two particular fields: Flow Cytometry and Nanobiotechnology...

The Journal of Biological Chemistry 11/2015:

The mechanisms of NLRP3 activation are still poorly understood. Jonathan Schmid-Burgk and colleagues present new data on the identification of NEK7, which specifically functions upstream of NLRP3 activation. NEK7 was identified in an unbiased genetic screening approach, which employed the CRISPR technology to identify macrophages that were rendered defective in NLRP3 signal transduction.